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. 2018 Apr 12;13(4):e0195698. doi: 10.1371/journal.pone.0195698

Fig 2. Anti-TERRA delays senescence in tlc1Δ mutants.

Fig 2

(A) Anti-TERRA expression delays senescence in tlc1 mutants by 10 PD (p = 0.0007). TLC1/tlc1Δ diploids carrying the inducible anti-TERRA plasmid were sporulated, and senescence assays of WT (n = 2) and tlc1Δ (n = 5) were performed as indicated in the Materials and Methods with anti-TERRA either induced or uninduced. (B) Induction alone does not delay senescence. TLC1/tlc1Δ diploids bearing an inducible control plasmid (which does not express anti-TERRA) were sporulated and senescence assays of WT (n = 2) and tlc1Δ (n = 5) were performed as indicated in the Materials and Methods with the control plasmid either induced or uninduced. In both panels, each data point represents the mean PD versus the mean and SEM of the cell density.