Table 3. (Primary analysis). Two-sample Mendelian randomization results for the odds of AAA per 1 SD increment in lipid fraction measures.
SNP—lipid associations are from the GLGC and SNP—AAA associations (adjusted for age, sex, and center) are from ARIC.
| Exposure | Method | OR | 95% CI | P | I2 (95% CI) | P for Q test | MR-Egger intercept (95% CI) | P |
|---|---|---|---|---|---|---|---|---|
| LDL cholesterol | MR-IVW | 1.55 | (1.08, 2.22) | 0.02 | 5% (0, 28%) | 0.35 | ||
| MR-Egger | 1.43 | (0.81, 2.49) | 0.21 | 0.01 (-0.03, 0.04) | 0.70 | |||
| MR-Weighted median | 1.59 | (0.93, 2.73) | 0.09 | |||||
| HDL cholesterol | MR-IVW | 0.68 | (0.42, 1.12) | 0.13 | 29% (7, 46%) | 0.007 | ||
| MR-Egger | 0.56 | (0.22, 1.42) | 0.22 | 0.01 (-0.03, 0.05) | 0.62 | |||
| MR-Weighted median | 0.62 | (0.32, 1.21) | 0.16 | |||||
| Triglycerides | MR-IVW | 1.08 | (0.64, 1.80) | 0.77 | 17% (0, 42%) | 0.15 | ||
| MR-Egger | 1.91 | (0.85, 4.32) | 0.12 | -0.03 (-0.07, 0.004) | 0.08 | |||
| MR-Weighted median | 1.09 | (0.50, 2.39) | 0.83 | |||||
| TC | MR-IVW | 1.48 | (1.02, 2.16) | 0.04 | 5% (0, 27%) | 0.36 | ||
| MR-Egger | 2.04 | (1.07, 3.87) | 0.03 | -0.02 (-0.05, 0.01) | 0.23 | |||
| MR-Weighted median | 1.66 | (0.92, 3.00) | 0.09 |
SD: standard deviation; LDL cholesterol: low-density lipoprotein cholesterol; HDL cholesterol: high-density lipoprotein cholesterol; TC: total cholesterol; IVW: inverse variance weighted
SDs from GLGC (LDL cholesterol: 38.7 mg/dL; HDL cholesterol: 15.5 mg/dL; triglycerides: 90.7 mg/dL; total cholesterol: 41.8 mg/dL)