Table 1. Area (mm2) and rate of wound contraction (RWC) (%) in animals treated with Strychnos pseudoquina extract at different concentrations.
| Sal | OV | SS | LE (5%) | LE (10%) | ||
|---|---|---|---|---|---|---|
| Day 0 | Area | 120.1±10,6 | 123.5±9.6 | 125.3±9.5 | 120±10.1 | 123.5±10.5 |
| RWC | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | |
| Day 7 | Area | 112.4±9.9 | 113.1±9.9 | 110.6±8.1 | 90.5±10.3* | 70.5±10.7* |
| RWC | 21.7±7.4 | 29.5±8.6 | 27.7±10.0 | 52.4±8.7* | 58.5±9.6* | |
| Day 14 | Area | 80.0±11.3 | 65.2±12.9 | 54.1±10.4 | 15.9±8.8* | 16.8±8.1* |
| RWC | 64.7±9.3 | 78.3±7.9 | 67.9±9.1 | 79.1±7.5 | 79.9±5.5 | |
| Day 21 | Area | 5.4±1.4 | 3.2±1.1 | 4.43±1.6 | 0.8±0.07* | 0.2±0.05* |
| RWC | 94.3±5.3 | 94.0±5.3 | 94.9±2.6 | 98.0±1.2 | 96.7±2.4 |
Tissue fragments were collected every seven days for 21 days of treatment. Sal: saline 0.9%; OV: ointment vehicle; SS: silver sulfadiazine (1%), LE 5: S. pseudoquina extract (5%); LE 10: S. pseudoquina extract (10%). The treatments were applied directly to the wounds for 21 days. F0 = intact tissue; F1, F2, F3 = cicatricial tissue after seven, 14 and 21 days, respectively. * Statistical difference vs. Sal, OV and SS.