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. 2018 Apr 12;13(4):e0195868. doi: 10.1371/journal.pone.0195868

Table 3. SPR-derived kinetic and equilibrium constants.

TCR variant KD (eq.) KD (kd/ka) ka (1/Ms) kd (1/s) Average KDa
scTCR wt380 27.3 ± 3.8x10-6 μM 32.5 μM 1.5x104 ± 1.6x102 0.5 ± 4.6x10-3 30 μM
scTCR s380 7.4 ± 7.0x10-8 μM 7.6 μM 9.5x104 ± 1.3x103 0.7 ± 9.8x10-3 7.5 μM

aAverage KD based on equilibrium and kinetic constants.