Table 3. SPR-derived kinetic and equilibrium constants.
TCR variant | KD (eq.) | KD (kd/ka) | ka (1/Ms) | kd (1/s) | Average KDa |
---|---|---|---|---|---|
scTCR wt380 | 27.3 ± 3.8x10-6 μM | 32.5 μM | 1.5x104 ± 1.6x102 | 0.5 ± 4.6x10-3 | 30 μM |
scTCR s380 | 7.4 ± 7.0x10-8 μM | 7.6 μM | 9.5x104 ± 1.3x103 | 0.7 ± 9.8x10-3 | 7.5 μM |
aAverage KD based on equilibrium and kinetic constants.