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. Author manuscript; available in PMC: 2018 Apr 12.
Published in final edited form as: Nat Rev Mol Cell Biol. 2017 Oct 11;19(3):192–206. doi: 10.1038/nrm.2017.94

Figure 1. Multiple levels of chromatin folding.

Figure 1

DNA compaction within the interphase nucleus occurs through a hierarchy of histone-dependent interactions, including the formation of the nucleosome core particle, strings of nucleosomes (bead-on-a-string arrangement), the chromatosome core particle and 30 nm fibres (the existence of which is debatable in vivo and which may only be relevant over short lengths of chromatin) and the association of individual fibres, which eventually produces tertiary structures.