Table 3.

Preconception blood pressure and fecundability, pregnancy loss and live birth by assignment to placebo or low-dose aspirin

Variable	Fecundability		Pregnancy loss*		Live birth
	Placebo group	LDA group	Placebo group	LDA group	Placebo group	LDA group
	FOR (95% CI)	FOR (95% CI)	RR (95% CI)	RR (95% CI)	RR (95% CI)	RR (95% CI)
Systolic blood pressure (10 mmHg)
Unadjusted	0.97 (0.89–1.07)	0.89 (0.81–0.97)	1.13 (0.99–1.30)	1.09 (0.94–1.25)	0.95 (0.89–1.02)	0.94 (0.88–1.00)
Adjusted†	1.04 (0.94–1.15)	0.94 (0.86–1.04)	1.10 (0.95–1.28)	1.05 (0.91–1.22)	0.98 (0.92–1.05)	0.97 (0.92–1.03)
Diastolic blood pressure (10 mmHg)
Unadjusted	0.89 (0.79–1.00)	0.92 (0.82–1.04)	1.37 (1.16–1.61)	1.06 (0.87–1.28)||	0.85 (0.79–0.92)	0.96 (0.89–1.04)||
Adjusted†	0.97 (0.86–1.10)	1.00 (0.88–1.14)	1.31 (1.09–1.57)	1.05 (0.86–1.28)‡	0.89 (0.82–0.97)	1.01 (0.94–1.10)||
Mean arterial pressure (10 mmHg)
Unadjusted	0.92 (0.82–1.03)	0.89 (0.79–1.00)	1.31 (1.12–1.55)	1.09 (0.90–1.32)	0.88 (0.81–0.95)	0.94 (0.88–1.02)
Adjusted†	1.00 (0.88–1.13)	0.97 (0.85–1.10)	1.27 (1.06–1.53)	1.07 (0.88–1.30)	0.92 (0.84–1.00)	0.99 (0.92–1.07)

^*Weighted by probability of pregnancy (predictors: systolic blood pressure, diastolic blood pressure, study group, age, BMI, race [white vs. non-white], marital status [married, living as married, other], cigarette smoking, parity, study site, number of prior losses and time from last pregnancy loss to enrollment [≤4 months, 5–8 months, 9–12 months, >12 months])

^†Adjusted for treatment assignment, age, BMI, race (white vs. non-white), marital status (married, living as married, other), cigarette smoking, parity and time from last pregnancy loss to enrollment (≤4 months, 5–8 months, 9–12 months, >12 months)

^‡Interaction P<0.1

^||Interaction P<0.05