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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Hypertension. 2018 Mar 26;71(5):877–885. doi: 10.1161/HYPERTENSIONAHA.117.10560

Figure 5. Restoration of serum Klotho levels inhibited upregulation of TGFβ-1 and Scleraxis on the aortic valve.

Figure 5

(A) IHC staining against TGFβ1 and SCXA (brown) on the aortic valves of AKR/J and SAMP1 mice treated with AAV.GFP or AAV.SKL. (B) Quantification of TGFβ1 and SCXA expression on the leaflets (N=4).Data=means±SEM. **p<0.01, ***p<0.001 vs. AKR/J; ++ p<0.01 vs. SAMP1+GFP.