Fig. 7.

Cldn7 deletion in the small intestine and large intestine induced by Tamoxifen caused adenomatous hyperplasia. The arrows show that atypical hyperplasia and adenoma could be observed in the intestinal tract (a–e). We have adjusted Tamoxifen at a dose of 100 μl in sunflower oil at 10 mg/ml per mouse (aged more than 8 weeks old) every four days. The large intestine epithelium structure of the solvent control group was intact and had no pathological changes (f).