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Signal transduction mechanism of EGFR transactivation by AngII in vascular smooth muscle cells leading to vascular remodeling. PTK; protein tyrosine kinase, PI3K; Phosphoinositide 3-kinase, p70S6K; p70 S6 kinase. Please note that in addition to this cascade both classical and novel pathways have been shown to contribute to AngII-mediated vascular remodeling (reviewed in detail recently in the reference 31).
