Fig. 6. Intestinal flora depletion affects steady-state hematopoiesis.
(A) Outline of abx-treatment of mice at steady-state without BMT. (B) Bone marrow cellularity, (C) number of bone marrow B cells (B220+), and (D) number of thymocytes in untreated specific pathogen free (SPF) mice (n = 14), AE-treated SPF mice (n = 15), untreated germ-free (GF) mice (n = 10) and AE-treated GF mice (n = 12) after 35 days of antibiotic treatment. (E) Weight of periovarian fat in untreated SPF mice (n = 10) and AE-treated SPF mice (n = 10) after 35 days of antibiotic treatment.
Results represent at least two independent experiments. * P < 0.05, *** P < 0.001, n.s. – Not significant. Data is presented as mean ± SEM. See also Figure S6.