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. 2018 Apr 12;8:5907. doi: 10.1038/s41598-018-24074-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Engraftment of hΔCD19-labeled RhiPSC-CMs into NSG mouse myocardial infarct area. (a–c) Incorporation of hΔCD19-labeled RhiPSC-CMs in the central myocardial infarct area. (a) H&E staining of the myocardial infarct at two months after LAD ligation and RhiPSC-CM transplantation. (b) Masson’s trichrome staining to visualize the infarcted cardiac tissue (blue color indicates fibrotic tissue). (c) Immunofluorescence staining of CD19 positive cells located throughout infarct area, these cells were also positive for cTnI co-staining. Scale bars, 500 µm. (d–f) Distribution of hΔCD19-labeled RhiPSC-CMs in the peri-infarct area. (d) H&E staining of the infarct area of heart tissue at two months after LAD ligation. (e) Masson’s trichrome staining to visualize the infarct area. (f) Immunofluorescence staining revealed CD19 (red) positive cells were outside the infarct area but positive with cTnI co-staining. Scale bars, 400 µm.