Fig. 6.
Bumetanide attenuates electrical network and behavioral effects of dopamine deprivation. Nicotinic receptor antagonists a, c or bumetanide b, d treatment blocked giant GABAergic PSCs recorded in SPNs (6-OHDA-treated mice) at VH = + 10 mV. e, f Behavioral tests. e Time to traverse roller in control and 6-OHDA-treated mice (same 6-OHDA-treated mice before and after bumetanide treatment). f Pole test score of the three different mouse groups. See Supplementary Movies 2-7. All means ± SEM. c, d Significance was determined by two-tailed, paired Student’s t-test; see Supplementary Tables 19 and 20 for statistics. e Significance was determined by two-tailed unpaired (left set) or paired (right set) Student’s t-test; see Supplementary Table 21 for statistics. f Data sets were analyzed using one-way ANOVA followed by Fisher’s least significant difference (LSD) post-hoc test; see Supplementary Table 22 for statistics; *P < 0.05, **P < 0.01, ***P < 0.001. NS, not significant