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. 2018 Apr 13;3:9. doi: 10.1038/s41392-018-0010-0

Fig. 5. Effects of roniciclib–cisplatin combinations in vivo.

Fig. 5

a BALB/c nude mice were subcutaneously injected with HONE-1 cells. Dosing schedules are shown in the figure. b Mouse weights (g) were monitored throughout the study. (*) denotes statistical significance (p value <0.05). c Protein expression of direct cell cycle substrates on mouse tumor tissues harvested 24 h after the first and second treatment cycles, respectively. BALB/c nude mice were subcutaneously injected with HONE-1 cells. Mice were treated at 0.5 mg/kg and 1 mg/kg twice daily every 3 days on/4 days off