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. 2018 Apr 12;8:5891. doi: 10.1038/s41598-018-23699-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Seed-based functional connectivity differences for each region of interest between PIs and GSs. Note: Betweent-group differences in functional connectivity using the four ROIs that differ from binarized degree centrality, including right middle temporal gyrus (A), left middle temporal gyrus (B), right insula (C), and left superior frontal gyrus (D) with whole brain. Abbreviations: R, right; L, left; PIs, Patients with primary insomnia; GSs, Good sleepers; ROI, Region of interest.