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. 2018 Apr 12;8:5898. doi: 10.1038/s41598-018-24273-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Deposition of C3b/c, C4b/c, and C6 on PAEC assessed by immunofluorescence after perfusion with NHS with or without complement inhibitors. Column graphs on the left panels show quantification of immunofluorescence staining for deposition of C3b/c (A), C4b/c (B) and C6 (C). Shown are mean values ± SD with indication of statistically significant differences between complement inhibitor groups and NHS alone. ****p < 0.0001, n = 5. Representative images are shown on the right panels. PAEC in microfluidic channels were perfused for 60 min with 1:10 NHS + C1 INH (a), 1:10 NHS + APT070 (b), 1:10 NHS + DXS (c), and 1:10 NHS alone (d). Sera from different donors with different blood groups were used as pool of 8 donors. Scale bar represents 50 µm.