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. 2018 Apr 12;8:5916. doi: 10.1038/s41598-018-24080-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The MMP14 biosensor is trafficked through normal exocytic and endocytic pathways. (a–c) Whole-cell image overlays (far left) and zoomed regions of the cell (white boxes) showing colocalization imaging of HUVECs expressing the MMP14 biosensor, MG2P dye, and a fluorescent marker for either the endoplasmic reticulum (ER; a), the Golgi-apparatus (b), or lysosomes (c). The color of the text in each panel indicates the fluorescent color shown in the Overlay images. (d–e) Quantification of the total number of MMP14 biosensor and dye-bound biosensor and their distributions in ER (n = 6), Golgi (n = 5), lysosomes (n = 4), and the plasma membrane (PM; n = 15). (e) Distributions of MMP14 biosensor and dye-bound biosensor shown as a percentage of the total MMP14 biosensor localized within each of the cellular organelles. Scale bars = 20 µm (whole cell); 5 µm (zoomed). P < 0.01. Error bars = + /− SD.