Table 1.

Pharmacokinetic parameters of GA in normal and ISO-induced myocardial infarcted rats after oral administration of 50 and 100 mg/kg GA, respectively (mean ± SD, n = 8).

Pharmacokinetic parameters	Units	GA (50 mg/kg)		GA (100 mg/kg)
		Normal	MI	Normal	MI
Cmax	μg⋅mL–1	0.83 ± 0.15	0.32 ± 0.11*	1.71 ± 0.29	0.72 ± 0.19*
Tmax	min	90.00 ± 21.21	102.00 ± 15.49	85.00 ± 12.25	96.00 ± 13.42
T1/2	min	153.65 ± 19.45	244.51 ± 26.23*	186.67 ± 23.97	278.17 ± 26.86*
AUC0–t	mg⋅min⋅L–1	137.07 ± 24.75	83.41 ± 18.17*	262.55 ± 22.05	198.99 ± 24.69*
AUC0–∞	mg⋅min⋅L–1	150.49 ± 26.35	121.62 ± 17.16	280.49 ± 26.35	300.52 ± 37.33
MRT0–t	min	160.08 ± 18.58	238.58 ± 14.89*	176.64 ± 24.03	274.77 ± 7.29*
MRT0–∞	min	187.97 ± 21.75	301.21 ± 42.29*	211.58 ± 24.54	331.21 ± 43.89*
CL	L⋅(min⋅kg)–1	0.37 ± 0.08	0.29 ± 0.10	0.43 ± 0.06	0.34 ± 0.04*
Vd	L⋅kg–1	78.52 ± 8.51	131.09 ± 24.16*	89.60 ± 10.53	113.09 ± 13.58*

^∗p < 0.05 compared with respective normal rats.