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. 2018 Apr 6;9:148. doi: 10.3389/fendo.2018.00148

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Copyright © 2018 Terasawa, Garcia, Seminara and Keen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in release of GnRH and kisspeptin (area under the curve in response to challenge of secretagogues). GnRH in response to human kisspeptin-10 (hKP10) (A) and senktide (B) in female rhesus monkeys are shown. Kisspeptin response to senktide (C) is also shown. ***p < 0.001; ****p < 0.0001 vs. vehicle control (within a group). ^####p < 0.0001 vs. lower dose (within a group). aa: p < 0.01; aaa: p < 0.001; aaaa: p < 0.0001 vs. prepubertal stage (between groups at the same dose of challenge). Modified from Ref. (35) with data from Ref. (34) with Copyright Permission.