Figure 1.

Infection elicits CD4 T cells of broad epitope diversity. Female A/J mice (aged 2–6 months) were infected intranasally with 50,000 EID₅₀ of A/New Caledonia/20/99 H1N1 virus, and the number of peptide-specific cytokine producing cells from the spleen were quantified. IL-2 cytokine EliSpots (A) are quantified in the top panel and IFN-γ producing cells (B) are shown in the bottom panel. Results are represented as cytokine-producing spots per million CD4 T cells and represent the average of two independent experiments with the range indicated.