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. 2018 Apr 12;8:5922. doi: 10.1038/s41598-018-24020-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Myocardial apoptosis in infarction border zone, eight weeks post-modeling. (A) Myocardial apoptosis in infarct border zone, TUNEL staining, 200×. (A1) Control group. (A2) Low dose group. (A3) Middle dose group. (A4) High dose group. (B) Expression of Bcl-2 mRNA in infarction border zone measured by RT-PCR CON = control, LOW = low dose group, MID = middle dose group, and HIGH, high dose group. *p < 0.05 compared with control group, ^#p < 0.05 compared with low dose group, and ^Δp < 0.05 compared with high dose group. (C) Expression of Bax mRNA in infarction border zone measured by RT-PCR CON = control, LOW = low dose group, MID = middle dose group, and HIGH, high dose group. *p < 0.05 compared with control group, ^#p < 0.05 compared with low dose group, and ^Δp < 0.05 compared with high dose group. (D) Expression of Akt in infarction border zone measured by western blot. CON = control, LOW = low dose group, MID = middle dose group, and HIGH, high dose group. *p < 0.05 compared with control group, ^#p < 0.05 compared with low dose group, and ^Δp < 0.05 compared with high dose group.