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. 2018 Apr 12;8:5885. doi: 10.1038/s41598-018-24156-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Targets Selected for Analysis of Aberrant Alternative Splicing. Three categories of alternative exons selected are shown: early responding exons (INSR E11 and SOS1 E25); medium responding exons (CACNA1S E29, ANK2 E21, PHKA E28 and MBNL1 E7), and late responding exons (KIF13A E32 and ARHGEF7 3′UTR). N, normal samples; PM, samples from pre-mutation carriers and DM patients with increasing disease severity. The agarose gel separation of representative RT-PCR products for alternative exon inclusion and exclusion in non-DM (sample 6A, female, tibialis anterior) and DM1 (sample 3A; adult onset, male, tibialis anterior; 390 CTG repeats) is shown.