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. 2018 Apr 6;9:308. doi: 10.3389/fphar.2018.00308

FIGURE 1.

FIGURE 1

Effect of DHI on tPA-dependent plasmin generation in vitro and acute brain tissue outcomes of different combination therapy in stroke rats. (A) A range of concentrations of tPA (1, 2.5, 5, and 10 μg/mL) with or without the indicated concentrations of DHI (1, 2, 3, and 4 μL/mL) were added to wells of 96-well plate. Plasmin activity was represented as fold of plasmin activity related to 1 μg/mL of tPA alone. (B) At 24 h after stroke, neurological score were quantified. (C) Ischemic infarct volume rates were quantified at 24 h after stroke. (D) Brain edema was assessed at 24 h after stroke. Data were expressed as mean ± SD, n = 6 per group. ∗P < 0.05, ∗∗P < 0.01 vs. vehicle group. &&P < 0.01 vs. sham group. #P < 0.05, ##P < 0.01 vs. DHI-M+tPA-M.