Figure 4.

Iron contents in peripheral organs and brain regions in 2-month and 12-month mice with dietary iron supplement for 3 months. (A) Iron contents in peripheral organs and brain regions in 2-month mice with dietary iron supplement: Iron contents were increased in the liver and spleen (peripheral organs) in 2-month WT mice with high dietary iron supplement for 3 months. Although no changes were observed in the other brain regions, iron contents were elevated in the cortex and striatum of 2-month mice with high dietary iron for 3 months. Each bar represented the mean ± SEM. *P < 0.05, compared with the corresponding basal dietary iron group; n = 6. (B) Iron contents in peripheral organs and brain regions in 12-month mice with dietary iron supplement: Iron contents were increased in the plasma. Iron contents in the SN were obviously higher than the other brain regions in 12-month mice with basal dietary iron and high dietary iron for 3 months. Each bar represented the mean ± SEM. *P < 0.05, compared with the corresponding basal dietary iron group; ^#P < 0.05, compared with the other brain regions of mice with basal dietary iron; ^∧P < 0.05, compared with the other brain regions of mice with high dietary iron; n = 6.