Skip to main content
. 2018 Apr 6;12:9. doi: 10.3389/fnsys.2018.00009

Figure 3.

Figure 3

CXC chemokine (CXCL9, CXCL10, CXCL11) protein expression in whole urinary bladders of female (A) and male (B) mice following CYP treatment of varying duration (4 h, 4 h, 48 h, chronic) as determined with enzyme-linked immunosorbent assays. CXCL9 and CXCL10 chemokine protein expression increased significantly (*p ≤ 0.01) in whole urinary bladder following 4 h CYP treatment in female mice (A) compared to control (*p ≤ 0.01) and 48 h and chronic treatments (#p ≤ 0.01). CXCL9, CXCL10 and CXCL11 protein expression in urinary bladder was significantly (*p ≤ 0.01) decreased with 48 h and chronic CYP treatment compared to control females (A). Sample sizes are n = 6–8 for each group. CXC (CXCL9, CXCL10, CXCL11) protein expression in whole urinary bladders of male mice was not regulated following CYP-induced cystitis of any duration evaluated (B). CXC protein (CXCL9, CXCL10, CXCL11) expression in female whole urinary bladder was significantly (p ≤ 0.01) greater than expression in male urinary bladder under control conditions (A,B). Sample sizes are n = 6–8 for each group. ELISAs for CXC chemokines in urinary bladder of male mice were repeated with an additional n = 6–8 mice per group.