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. 2018 Apr 6;12:9. doi: 10.3389/fnsys.2018.00009

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Copyright © 2018 Guo, Chang, Hauke, Girard, Tooke, Ojala, Malley, Hsiang and Vizzard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative cystometrogram recordings using continuous intravesical infusion of saline in conscious, female mice with an open outlet following CYP-treatment (48 h) before (pre A1,A2) and after (post B1,B2) intravesical CXCR3 receptor blockade with AMG487 (5 mg/kg). (A) Volume infused (μl; A1,B1) and bladder pressure (cm H₂0; A2,B2) before (vehicle; A1,A2) and after AMG487 (5 mg/kg) instillation (B1,B2) in a female mouse treated with CYP 48 h. Bladder function recordings in (A1,A2) and (B1,B2) are from the same mouse. Arrows (A2,B2) indicate appearance of non-voiding contractions (≥5 cm H₂0 without the release of urine during the filling phase).