Table 4.
pD2 and Emax (mN) values of sodium nitroprusside-induced relaxation and phenylephrine-induced contraction in thoracic aorta arteries, from Control or High Sugar-fed rats, incubated with vehicle or L-NAME.
| pD2 | Emax | |||
|---|---|---|---|---|
| Groups | 10 Weeks | 12 Weeks | 10 Weeks | 12 Weeks |
| Control PVAT (–) (Sodium nitroprusside) | 7.5 ± 0.05 (n = 6) | 7.6 ± 0.05 (n = 6) | 92.8 ± 2.0 (n = 6) | 95.8 ± 1.9 (n = 6) |
| High Sugar PVAT (–) (Sodium nitroprusside) | 7.6 ± 0.05 (n = 7) | 7.4 ± 0.06 (n = 7) | 96.4 ± 1.9 (n = 7) | 94.7 ± 2.3 (n = 7) |
| Control PVAT (+) (Sodium nitroprusside) | 7.4 ± 0.02 (n = 6) | 7.5 ± 0.02 (n = 6) | 97.1 ± 1.1 (n = 6) | 98.1 ± 1.1 (n = 6) |
| High Sugar PVAT (+) (Sodium nitroprusside) | 7.3 ± 0.08 (n = 7) | 7.3 ± 0.07 (n = 7) | 92.7 ± 2.0 (n = 7) | 92.8 ± 2.9 (n = 7) |
| Control PVAT (+) | 8.1 ± 0.09 (n = 6) | 8.1 ± 0.05 (n = 6) | 21.3 ± 0.7 (n = 6) | 23.1 ± 0.4 (n = 6) |
| Control PVAT (+) (L-NAME) | 8.1 ± 0.08 (n = 7) | 8.3 ± 0.06 (n = 7) | 26.1 ± 0.7 (n = 7)+ | 33.5 ± 0.7 (n = 7)+ |
| High Sugar PVAT (+) | 8.2 ± 0.04 (n = 6) | 8.0 ± 0.07 (n = 6) | 26.2 ± 0.4 (n = 6) | 34.9 ± 0.9 (n = 6) |
| High Sugar PVAT (+) (L-NAME) | 8.1 ± 0.06 (n = 7) | 8.2 ± 0.04 (n = 7) | 27.4 ± 0.6 (n = 7) | 35.7 ± 0.5 (n = 7) |
Data represent the mean ± SEM of n experiments. Two-way ANOVA:
+
p < 0.05 vs. respective Control PVAT (+).