FIGURE 6.

Collagen biosynthesis measured as 5[³H]-proline incorporation into proteins susceptible to the action of bacterial collagenase in CAL-27 cell culture incubated for 24 h with polyphenols in following concentrations: chrysin – 5 μg/mL, caffeic acid – 65 μg/mL, ferulic acid – 50 μg/mL, and p-coumaric acid – 70 μg/mL. 2-Metoxyestradiol (MOE) (10 μM) was used as a positive control. The values represent mean ± SEM of two independent experiments conducted three times (n = 6). The stars indicate values significantly different from control (^∗p < 0.001).