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. 2018 Apr 12;8:5927. doi: 10.1038/s41598-018-24257-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Suppression of the inflammatory response in the kidney of Sirt7 KO mice. (A) Slc22a2 and Slc47a1 mRNA expression in mouse kidneys was determined by real-time PCR (n = 5/group). (B) Oxidative stress-related mRNA expression in mouse kidneys was determined by real-time PCR (n = 5/group). (C) Inflammation-related mRNA expression in mouse kidneys was determined by real-time PCR (n = 5/group). (D) Representative photomicrographs (×400) of immunostaining for F4/80 in kidney sections. F4/80-positive cells were counted in 4 randomly selected fields per section (n = 3/saline group, n = 5/cisplatin group). The arrows indicate F4/80-positive cells. Scale bars: 50 µm. The abundance of each mRNA type was normalized using GAPDH. *p < 0.05, **p < 0.01. Data are expressed as the mean ± SEM.