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. 2018 Apr 12;8:5927. doi: 10.1038/s41598-018-24257-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of Sirt7 decreases the expression of TNF-α in cisplatin-treated NRK-52E cells. (A) SIRT7 protein expression in shRNA-introduced NRK-52E cells was evaluated by western blot analysis. (B) Oxidative stress-related mRNA expression in shRNA-introduced NRK-52E cells was determined by real-time PCR (n = 4/group). (C) Inflammation-related mRNA expression in shRNA-introduced NRK-52E cells was determined by real-time PCR (n = 4/group). The abundance of each mRNA type was normalized using GAPDH. *p < 0.05, **p < 0.01. Data are expressed as the mean ± SEM.