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. 2018 Apr 12;8:5927. doi: 10.1038/s41598-018-24257-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nuclear accumulation of p65 is suppressed in the kidney of cisplatin-treated Sirt7 KO mice. (A) Protein expression of p65 in the nuclear fraction of mouse kidney was evaluated by western blot analysis. H3 was used as a loading control (n = 5/group) (B) Nuclear p65 protein expression in tubular cells was evaluated by p65 immunostaining (n = 5/group). The arrows indicate p65-expressing nuclei. Scale bars: 50 µm. *p < 0.05, **p < 0.01. Data are expressed as the mean ± SEM.