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. 2018 Apr 6;9:667. doi: 10.3389/fmicb.2018.00667

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Copyright © 2018 Reis, Boff, Verly, Melo-Braga, Cortés, Santos, Pimenta, Amaral, Resende and de Lima.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LyeTxI-b decreases bacteria load and cellular recruitment to the joint. The arthritis was induced by intra-articular injection of S. aureus (10⁷ CFU/10 μL) in mice. The treatment with LyeTxI-b (0.03 nmol) and clindamycin, Clin (7 nmol) by ipsilateral joint injection was performed every other day, starting on day 1, after arthritis induction. The analyses were performed 7 days after S. aureus injection for (A) bacterial load in whole joint and, (B) total cells, (C) neutrophils and (D) mononuclear cells accumulated into the joint cavity. ^∗∗∗p < 0.05 compared to non-infected mice; ^#p < 0.05 compared to saline-treated infected mice. n = 6–8 mice per group. CFU, colony-forming unit (definir); Sal, saline; NI, non-infected mice.