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. Author manuscript; available in PMC: 2018 Apr 13.
Published in final edited form as: Exp Parasitol. 2015 Mar 24;153:139–150. doi: 10.1016/j.exppara.2015.03.012

Figure 4. Schistosomal calpain-like protease generates SG-sCD23.

Figure 4

A. Leupeptin (5µg/ml) inhibits SEA-mediated reduction of surface CD23 on tonsil MC (18 hr culture). Shown are CD23 levels on monocytes. B. Leupeptin inhibits live schistosomula from reducing surface CD23 on purified tonsil B cells (representative of 5 separate experiments; 18 hr culture; *P<0.05 compared to no treatment). C. Leupeptin inhibits the generation of SG-sCD23 from tonsil B cells; 18 hr culture. D. High titer polyclonal anti-Sm-p80 from immunized mice inhibits the generation of SG-sCD23 from PBMC (18 hr culture; n=6 blood samples; *P<0.01 compared to no treatment). Plot depicts densitometry from Western blot probed with anti-CD23.