Table 1. Significance of Notch signalling pathway genes in cancer.
| Ligands | Function | Reference |
|---|---|---|
| DLL 1 | Governing cell fate decisions and cell-to-cell communication | (15) |
| DLL 3 | Suppressing cell growth by apoptosis induction | (13) |
| DLL 4 | Activating NF-κΒ signalling to enhance VEGF; secretion and promote metastasis | (14,16) |
| JAG 1 | Interaction with Notch2 to promote cell survival | (15) |
| JAG 2 | Interaction with Notch2 to promote cell survival and proliferation | (12) |
| Receptors | Transmembrane receptor involved in cell | (17-19) |
| Notch1 | proliferation, invasion and chemo resistance | (20) |
| Notch2 | Constitutive Notch2 signalling induces hepatic tumours | (13) |
| Notch3 | Promoting proliferation and migration, and modifying chemotherapy response | (21) |
| Notch4 | Involved in endocrine therapy resistance and EMT in breast cancer | (13,22) |
| Hes1 | Sequence-specific DNA binding transcriptional factor involved in cellular proliferation and differentiation | (23) |
| Hey1 | Hes-related transcriptional factor involved in neoplastic vasculature development | (23) |
VEGF, vascular endothelial growth factor; EMT, epithelial-mesenchymal transition.