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. 2018 Mar 6;37(8):e97902. doi: 10.15252/embj.201797902

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© 2018 The Authors. Published under the terms of the CC BY 4.0 license

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(1) TACC3 docks to Aurora‐A through a motif centred on F525 and L532. (2) Activated Aurora‐A phosphorylates TACC3 on S558. (3) Phosphorylated TACC3 has increased helical propensity. (4) The helical conformation of TACC3 docks to CHC via hydrophobic residues L559, Y560 and F563.