Table 4.
Treatment Options in 4 Groups of Patients With Idiopathic CD4 Lymphocytopenia
| CD4 count | Clinical manifestations | Treatment |
|---|---|---|
| Group 1: no treatment | ||
| 273 | thyroid cancer | none |
| 230 | neuropathy, Molluscum contagiosum | none |
| 294 | skin fungal infection | none |
| Group 2: trimethoprim and sulfamethoxazole + fluconazole or azithromycin | ||
| 4 | corneal herpes zoster, HPV, recurrent vaginal candidiasis, UTIs | trimethoprim and sulfamethoxazole + dapsone + azithromycin + Valtrex |
| 21 | genital warts, HPV, Molluscum sp, candidiasis | trimethoprim and sulfamethoxazole + azithromycin + fluconazole |
| 32 | cryptococcal meningitis | trimethoprim and sulfamethoxazole + fluconazole + clarithromycin |
| 37 | chronic herpetic lesions | trimethoprim and sulfamethoxazole + fluconazole + azithromycin |
| 60 | cryptococcal meningitis | trimethoprim and sulfamethoxazole + fluconazole |
| 74 | bacterial pneumonia, fungal infection | trimethoprim and sulfamethoxazole + azithromycin |
| 80 | cryptococcal skin infections | trimethoprim and sulfamethoxazole + fluconazole |
| 82 | bronchitis, otitis, folliculitis | trimethoprim and sulfamethoxazole + acyclovir + steroid |
| 89 | pneumonia | trimethoprim and sulfamethoxazole |
| 103 | neurological disease | trimethoprim and sulfamethoxazole |
| 113 | lymphoma | trimethoprim and sulfamethoxazole |
| 120 | nail fungal, thrombophlebitis | trimethoprim and sulfamethoxazole |
| 142 | MAC and Pneumocystis jirovecii pneumonia | trimethoprim and sulfamethoxazole |
| 186 | herpes simplex esophagitis | trimethoprim and sulfamethoxazole + azithromycin + valacyclovir |
| 197 | chronic persistent plantar warts, EBV infection | trimethoprim and sulfamethoxazole + fluconazole |
| Group 3: IL-2 ± antibiotics | ||
| 27 | cryptococcal osteomyelitis | IL-2 + trimethoprim and sulfamethoxazole + azithromycin |
| 29 | Mycobacterium gordonae, bronchiectasis | IL-2 |
| 87 | venereal warts, anemia, ITP | IL-2 + IVIG + fluconazole |
| 188 | severe warts | IL-2 + trimethoprim and sulfamethoxazole |
| Group 4: IVIG | ||
| 87 | ITP, venereal wart, anemia | IVIG + IL-2 + fluconazole |
| 160 | CIPD | IVIG + trimethoprim and sulfamethoxazole |
| 230 | CIPD, erythema multiform | IVIG + hydroxychloroquine |
Abbreviations: CIPD, chronic inflammatory demyelinating polyneuropathy; EBV, Epstein-Barr virus; HPV, human papillomavirus; IL-2, interleukin-2; ITP, immune thrombocytopenia; IVIG, intravenous immunoglobulin; MAC, mycobacterium avium complex; UTI, urinary tract infection.