Table 2.

Characteristics and methodological quality of studies

Study author	Patients treated with oxaliplatin (n)	Study design	Oxaliplatin treatment schedule/regimen	Study quality score
Andre [14]	97	Prospective	FOLFOX3 or FOLFOX4 (85 mg/m2 as a 2 h infusion day1, repeated every 2 weeks)	11
Argyriou [17]	170	Prospective	FOLFOX4 (Oxaliplatin: 85 mg/m2 as a 2 h infusion on day1, repeated every 2 weeks)	11
Argyriou [32]	150	Prospective	FOLFOX/XELOX (OX dose) = NR	11
Davidov [38]	26	Prospective	FOLFOX (Oxaliplatin: 85 mg/m2 as a 2 h infusion on day1, repeated every two weeks).	8
Diaz-Rubio [11]	25	Prospective	Oxaliplatin (130 mg/m2 as a 2 hour infusion on day1, repeated every 3 weeks)	10
Land [36]	395/2492	Prospective	FOLFOX (Oxaliplatin: 85 mg/m2 IV infusion on day 1 of week 1, 3 and 5 of each 8 week cycle for three cycles)	10
Levi [15]	93	Prospective	FOLFOX (25 mg/m2/day infusion for 5 days, repeated every 3 weeks)	12
Pfeiffer [29]	70	Prospective	XELOX (Oxaliplatin: 130 mg/m2 as a 30 min infusion on day1, repeated every 3 weeks)	8
Ravaioli [33]	45	Prospective	FOLFOX (Oxaliplatin: 130 mg/m2 as a 2 h infusion day1, repeated every 3 weeks)	12
Rothenberg [8]	463	Prospective	Oxaliplatin (85 mg/m2 as a 2 h infusion on day1, repeated every 2 weeks) and FOLFOX (85 mg/m2 as a 2 h infusion on day1, repeated every 2 weeks)	11
Schmoll [37]	1864	Prospective	XELOX (Oxaliplatin: 130 mg/m2 as a 2 h infusion on day1, repeated every 3 weeks)	10
Shields [34]	48	Prospective	XELOX (Oxaliplatin: 130 mg/m2 as a 2 h infusion on day1, repeated every 3 week)	11
Sorbye [35]	85	Prospective	FOLFOX (Oxaliplatin:85 mg/m2 as a 2 h infusion day1, repeated every 2 weeks)	10
Storey [25]	188	Retrospective	XELOX (Oxaliplatin: 130 mg/m2 2 h infusion on day 1, repeated every 3 weeks)	10

FOLFOX Folinic acid (Leucovorin); Fluorouracil; Oxaliplatin (OX), XELOX Capecitabine (Xeloda); Oxaliplatin (OX), NR Starting dose of the regimen was Not Reported