Table 1.

Overview of exemplary models for cancer research

	References
In vivo
Murine models	[37]
Genetically engineered mouse model	[36]
Zebra fish model	[42]
Drosophila model	[41]
Chick embryo model	[43, 44]
In vitro
General 2D/3D in vitro models	[46, 53]
Transwell model	[48]
Spheroid system	[49]
Microfluidic system	[50]
Tissue-engineered microvessel model	[51]
In silico
Sequence analysis	[63, 69, 74]
General pathway analysis and network inference	[132, 133, 135]
Pan-cancer	[62, 82, 134, 139]
Chemical perturbation mapping	[64, 66, 68]
Pharmacogenomic mapping	[99, 102, 117, 136]
Genome-phenotype mapping	[81]
Clinical data integration	[106]
Structure mapping	[102, 103]
Structure and activity	[100, 101]
Framework for key events and mode of action	[97, 98]
Image classification	[85, 87]
Growth prediction	[91–93]