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. 2018 Apr 12;9:103. doi: 10.1186/s13287-018-0831-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — PTX uptake by DPSCs (Step 1). Incubation for 12 h with 10 μM PTX PBS solution, 60× water immersion objective. a Integrated Raman intensities in 2800–3000 cm⁻¹ region of cells corresponding to C–H mode. b KMCA image to detect intracellular PTX (pink spots). c Pearson’s correlation map between whole cell Raman spectra and reduced cytochrome c Raman spectrum. Highest correlation obtained for red spots (indicated by black arrows). Region with no correlation to cytochrome c (navy blue) corresponds to fresh PBS buffer. d Mitochondria cluster (black) obtained from KMCA. e Mitochondria cluster overlapped in correlation map of cytochrome c; all positions corresponding to cytochrome c completely covered by the mitochondria cluster that indicates localization of cytochrome c within mitochondria