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. 2018 Apr 12;19:65. doi: 10.1186/s12931-018-0770-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Graphical representation of Unified Theory analysis for BDP/FF combination administered at 100:6 concentration-ratio reporting the logarithmic Combination Index plot (a and b) and the normalized isobologram (c and d) in non-sensitized (a and c) and passively sensitized (b and d) human medium bronchi submaximally contracted by histamine. Points represent the mean ± SEM of n = 5 sub-segmental bronchi from different subjects; the labels of points report the weight/weight ratio (ng/ng) between BDP and FF. BDP: beclomethasone dipropionate; CI: Combination Index; Fa: fraction affected; FF: formoterol fumarate. Fu: fraction unaffected