Fig. 6.

Representation by STRING software of differentially abundant proteins overexpressed in NR compared to TR (https://string-db.org/). The nature of the interactions is shown at the bottom left of the figure and lists the known interactions (from curated database, experimentally determined), the predicted interactions (gene neighbourhood, gene fusion, gene co-occurrence) and the others (text mining, co-expression, protein homology). Overexpressed proteins were found in NR versus TR with a ribosomal proteins (RPS and RPL), b NDUF mitochondrial respiratory chain complex I proteins and c DPYD, the enzyme responsible for 5-FU hepatic catabolism. 5-FU 5-fluorouracil, DPYD dihydropyrimidine dehydrogenase, NR non-responders, RPL 40S ribosomal protein, small subunit, RPS 60S ribosomal protein, large subunit, TR total responders