Fig. 4.

ROC curve analysis was performed to evaluate the contribution of SATB2, CK20 and CDX2 expression when diagnosing the origin as colorectal cancer. (A) ROC curve of SATB2 expression [area under curve (AUC) = 0.977, p < 0.0001] in CRCs compared to non-CRCs in the resection cohort. (B) ROC curves of SATB2 (AUC = 0.948, p < 0.0001), CK20 (AUC = 0.959, p < 0.0001), and CDX2 (AUC = 0.976, p < 0.0001) expression, as well as a combination of all three markers (AUC = 0.986, p < 0.0001), in liver needle biopsies from patients with liver metastases with CRC origins versus other origins. ROC, receiver operating characteristics.