Table 2.
Malariometric indices of clinical and asymptomatic infections during the first year of life
| Age groups | Total | ||||
|---|---|---|---|---|---|
| 0–3 months | 3–6 months | 6–9 months | 9–12 months | ||
| Longitudinal survey (N = 734) | |||||
| Clinical episodes by qPCR [number (% out of total cases)] | 50 (7) | 122 (17) | 231 (32.2) | 314 (43.8) | 717 (100) |
| Total time at risk (person-months) | 2197.07 | 2124.91 | 2056.62 | 1956.58 | 8335.18 |
| Incidence (per child-year) | 0.27 | 0.69 | 1.35 | 1.92 | 1.03 |
| Parasite density by qPCR [median (IQR)] | 1294 (116.5–6726) | 2848 (79.1–15,356) | 9044 (642–28,554) | 24,823 (3607–57,492) | 10,826.5 (876–38,021) |
| Sub-microscopic infections [number (% out of cases per age group)] | 12 (24) | 29 (23.8) | 39 (16.9) | 34 (10.8) | 114 (15.9) |
| Surveys timepoints | Total | ||||
|---|---|---|---|---|---|
| 3 months | 6 months | 9 months | 12 months | ||
| Cross-sectional surveys | |||||
| Total participants per survey | 678 | 631 | 587 | 638 | 2534a |
| Asymptomatic infections by qPCR [number (%)] | 120 (17.7) | 127 (20.1) | 108 (18.4) | 200 (31.3) | 555 (21.9)b |
| Parasite density by qPCR [median (IQR)] | 148 (4.2–1754) | 24.9 (1–954.7) | 454.9 (3.1–4524) | 1288 (2.6–13,998) | 347.8 (1.94–3534) |
| Sub-microscopic infections [number (% out of cases per survey)] | 58 (48.3) | 69 (54.3) | 49 (45.4) | 79 (39.5) | 255 (45.9) |
IQR interquartile range
a Total samples screened for asymptomatic infections
b Proportion of qPCR-positive samples out of total screened over the four cross-sectional surveys