Table 1.

Baseline and outcome parameters

	Baseline parameter	Blood parameter	Neurological assessment	NCSf Parameter	Subjective Score
Week 0	Age Gender Weight Size Comorbidity Medication Duration of disease (Diabetes and DPN)	HbA1ca	Clinical examination NSS NDSc	Bilateral amplitudes and NCVbof nn. surales and tibiales	NRSd
Week 6			Clinical examination NSSe NDS	Bilateral amplitudes and NCV of nn. surales and tibiales	NRS
Week 15	Change of medication	HbA1c	Clinical examination NSS NDS	Bilateral amplitudes and NCV of nn. surales and tibiales	NRS Adverse events
Weekly (treatment 1–10)	Change of medication				NRS Adverse events

^aHbA1c= glycated hemoglobin; ^bNCV = nerve conduction velocity; ^cNDS = neuropathy deficit score; ^dNRS = numeric rating scale; ^eNSS = neuropathy symptom score; ^fNCS = nerve conduction studies