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. 2018 Apr 12;16:98. doi: 10.1186/s12967-018-1466-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic illustrations of the domain structures and motifs of the Motin protein family and YAP1-2γ/TAZ. Because of the alternative splicing, AMOT-p80 is an N-terminal truncated protein of AMOT-p130. The N-terminal domain of AMOT-p130 contains LPTY motif and two PPEY motifs, which are required for YAP1-binding. Except for the Angiostatin-binding domain, AMOTL1 and AMOTL2 share sequence identity with AMOT-p130. In addition, all members of Motin possess a Bin/Amphiphysin/Rvs (BAR) domain. Prominent regions of YAP1-2γ/TAZ include WW domain(s), TEAD transcription factor-binding domain, transcriptional activation domain (TAD) and post synaptic density protein (PSD95) binding domain (PDZ BD). WW domains are required by AMOTs binding