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KLF2/KLF4 mediate transactivation of the HBA promoter. Luciferase reporter assay in bovine aortic endothelial cells (n=3–4 independent experiments). The HBA promoter activity was significantly enhanced in the cells when the HBA promoter was co-transfected with KLF2 and/or KLF4. Data are presented as mean ± standard error of the mean (SEM) values. **p < 0.01. KLF2, Kruppel-like factor 2 plasmid; KLF4, Kruppel-like factor 4 plasmid; HBA, hemoglobin subunit alpha.
