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. Author manuscript; available in PMC: 2018 Apr 13.
Published in final edited form as: Vasc Med. 2017 Aug 19;22(5):363–369. doi: 10.1177/1358863X17722211

Figure 5.

Figure 5

Critical KLF-binding sites on the HBA promoter. Luciferase activity of wild-type or mutant HBA promoter constructs co-expressed with either KLF2 (A) or KLF4 (B) were observed in bovine aortic endothelial cells (n=3–4 independent experiments). Gray boxes represent mutant KLF-binding sites on the HBA promoter. Data are presented as mean ± standard error of the mean (SEM) values. *p < 0.05 and **p < 0.01 when compared with a co-expression of wild-type HBA promoter with KLF2 or KLF4. KLF2, Kruppel-like factor 2 plasmid; KLF4, Kruppel-like factor 4 plasmid; HBA, hemoglobin subunit alpha; Luc, luciferase reporter; NS, not significant.