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Olfactory neurogenesis persisted in the squamous OM. Sections were labeled with antibody to olfactory marker protein (OMP) and imaged with a 40× objective. A. <1 pack year: the presence of OMP-immunoreactive (OMP-ir, green) olfactory sensory neurons (OSNs, arrows) in the olfactory epithelium, B. 1 pack year: layers of OMP-ir OSNs are present, and C. 9 pack years: the presence of abnormally-shaped OMP-ir OSNs (asterisk) near the apical squamous layer. DAPI = blue. Scale bar = 20µm.
