Figure 1.

Entry to the study, follow-up time and censoring for (i) hip fracture incidence and (ii) post-hip fracture mortality. The index date was defined as the first abnormal eGFR (<60 mL/min/1.73 m²) from a creatinine measured between 1 January and 31 December 2003. Where all eGFR values in 2003 were normal, the last value and date were taken as the index. Primary outcome, hip fracture incidence measured using (A) hip fracture admission (from hospital admissions data, where hip fracture was recorded as the main or additional diagnosis (ICD-10 code S72)) and (B) hip fracture-related death (from national death records, where hip fracture was recorded as a main or other cause of death). Secondary outcome, post-hip fracture mortality in individuals who had a hip fracture admission, both (A) all-cause mortality (ACM) and (B) specifically hip fracture-related mortality (HFM) where hip fracture was recorded as main or other cause of death. eGFR, estimated glomerular filtration rate; ICD-10, International Classification of Diseases, 10th Revision.