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The organization of the MHC-I region in the human and macaque genome. Each human chromosome expresses a single A, B, C, E and F allele. Macaques express equivalent E and F alleles but the A and B loci have expanded resulting in expression of multiple alleles from each locus. However, many of these alleles are expressed at very low levels and are termed minor alleles. These minor alleles appear to play a minimal role in the antiviral immune response.
