Table 3.
Association values between gene polymorphisms and clinical parameters.
| Polymorphism | N | BMI | Diagnosis age | HbA1c |
|---|---|---|---|---|
| ABCC8-Ala1369Ser | ||||
| A/A | 180 | 30.74 ± 6.84 | 46.23 ± 11.37 | 8.69 ± 2.07Δ |
| A/C | 241 | 29.84 ± 5.93 | 45.16 ± 11.34 | 8.34 ± 2.21 |
| C/C | 74 | 29.44 ± 5.26 | 43.20 ± 9.52 | 8.74 ± 2.09 |
| A/A+C/C | 254 | 30.36 ± 6.44 | 45.35 ± 10.93 | 8.70 ± 2.07
|
| CYP2C9-Arg144Cys | ||||
| C/C | 423 | 30.07 ± 6.26 | 45.41 ± 11.03 | 8.49 ± 2.17 |
| C/T | 67 | 30.30 ± 6.04 | 44.69 ± 11.40 | 8.67 ± 2.00 |
| T/T | 5 | 30.17 ± 2.09 | 40.00 ± 16.33 | 9.60 ± 2.13 |
| CYP2C9-Ile359Leu | ||||
| A/A | 460 | 30.06 ± 6.01 | 45.35 ± 10.96 | 8.52 ± 2.13 |
| C/A | 35 | 30.67 ± 8.28 | 44.06 ± 13.24 | 8.55 ± 2.34 |
| KCNJ11-Glu23Lys | ||||
| C/C | 179 | 30.70 ± 6.87 | 46.26 ± 11.56 | 8.64 ± 2.08 |
| C/T | 246 | 29.91 ± 5.96 | 44.95 ± 11.25 | 8.37 ± 2.19 |
| T/T | 70 | 29.26 ± 5.01 | 43.79 ± 9.28 | 8.75 ± 2.13 |
| C/C+T/T | 249 | 30.29 ± 6.42 | 45.56 ± 11.00 | 8.67 ± 2.09£ |
| KCNJ11-Ile1337Val | ||||
| C/C | 71 | 29.36 ± 5.05 | 43.75 ± 9.22 | 8.74 ± 2.12 |
| C/T | 247 | 29.97 ± 6.17 | 44.91 ± 11.34 | 8.38 ± 2.20 |
| T/T | 177 | 30.59 ± 6.62 | 46.34 ± 11.46 | 8.64 ± 2.07 |
| SLC22A1-Arg61Cys | ||||
| C/C | 475 | 30.05 ± 6.21 | 45.40 ± 11.03 | 8.53 ± 2.16 |
| C/T | 20 | 31.43 ± 5.83 | 41.90 ± 13.02 | 8.51 ± 1.77 |
| SLC22A1-Met61Val | ||||
| G/G | 92 | 30.77 ± 6.22 | 46.41 ± 9.96 | 8.18 ± 2.04 |
| A/G | 26 | 29.74 ± 4.45 | 45.58 ± 14.77 | 8.14 ± 1.74 |
| A/A | 6 | 28.66 ± 4.03 | 43.67 ± 10.65 | 8.15 ± 1.83 |
| SLC22A2-Ala270Ser | ||||
| A/C | 58 | 30.04 ± 6.35 | 46.03 ± 11.17 | 8.04 ± 1.56 |
| C/C | 437 | 30.11 ± 6.18 | 45.15 ± 11.12 | 8.59 ± 2.20 |
| SLC22A2-Met420Del | ||||
| ATG/ATG | 52 | 30.56 ± 6.30 | 44.65 ± 9.87 | 8.35 ± 2.09 |
| ATG/delTGA | 49 | 30.72 ± 5.77 | 48.10 ± 12.73 | 8.05 ± 2.00 |
| delGAT/delGAT | 23 | 29.61 ± 4.78 | 45.13 ± 9.59 | 8.02 ± 1.56 |
Data presented as mean ± SD. BMI: body mass index; HbA1c: hemoglobin A1c. ΔP = 0.029 (A/A vs. A/C), p = 0.012 (A/A+C/C vs. A/C), and £p = 0.039 (C/C+T/T vs. C/T).